1. Signaling Pathways
  2. Immunology/Inflammation
  3. Interleukin Related

Interleukin Related

IL

Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15589
    8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen
    Inhibitor
    8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen is a compound found in Citrus grandis. 8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen has significant anti-inflammatory activity, which mainly works by inhibiting the secretion of inflammatory factors IL-1β, PGE2 and TNF-α. 8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen can be used in the study of inflammation.
    8-(6,7-Dihydroxy-3,7-dimethyl-2E-octenyloxy)psoralen
  • HY-173334
    hMAO-B-IN-11
    Inhibitor
    hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 of 0.11 µM. hMAO-B-IN-11 acts through competitive binding to the hMAO-B active site, preventing oxidative deamination of monoamines and reducing hydrogen peroxide production. hMAO-B-IN-11 also inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia, hMAO-B-IN-11 is promising for research of neurodegenerative diseases like Parkinson’s and Alzheimer’s.
    hMAO-B-IN-11
  • HY-N7878
    Tectorigenin sodium sulfonate
    Inhibitor
    Tectorigenin sodium sulfonate is the product of tectorigenin sulfonated with sulfuric acid and mixed with saturated salt water. Tectorigenin sodium sulfonate has high water-solubility and good antioxidant properties.
    Tectorigenin sodium sulfonate
  • HY-170621
    STAT1/3-IN-1
    Inhibitor
    STAT1/3-IN-1 (Compound 6k) is a STAT1/3 phosphorylation inhibitor. STAT1/3-IN-1 inhibits the phosphorylation and nuclear translocation of STAT1/3. STAT1/3-IN-1 also inhibits inflammatory enzymes iNOS and COX-2. STAT1/3-IN-1 demonstrates anti-inflammatory effect (reduction of pro-inflammatory cytokines, including IL-1β, IL-6 and TNF-α) without significant cytotoxicity.
    STAT1/3-IN-1
  • HY-138971
    (±)17(18)-EpETE-ethanolamide
    Modulator
    (±)17(18)-EpETE-ethanolamide (17,18-EEQ-EA) (compound 17) is an ω-3 endocannabinoid epoxide with cytokine modulation in neuroinflammation studies, antiangiogenic effects in vascular endothelial cells, and vasodilatory effects on coronary arteries.
    (±)17(18)-EpETE-ethanolamide
  • HY-18325A
    AN-3485 hydrochloride
    Inhibitor
    AN-3485 hydrochloride is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 hydrochloride can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 hydrochloride also has certain anti-tumor activity.
    AN-3485 hydrochloride
  • HY-P990452
    Anti-IL-5 Antibody
    Inhibitor
    Anti-IL-5 Antibody is a CHO-expressed humanized antibody that targets IL-5. The Anti-IL-5 Antibody is composed of huIgG4 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-IL-5 Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-IL-5 Antibody
  • HY-RS06767
    Il4 Rat Pre-designed siRNA Set A
    Inhibitor

    Il4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Il4 Rat Pre-designed siRNA Set A
    Il4 Rat Pre-designed siRNA Set A
  • HY-P991280
    BMS-981164
    Inhibitor
    BMS-981164 is a human IgG1-kappa anti-IL31 monoclonal antibody. The isotype control of BMS-981164 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). BMS-981164 can be used in research related to atopic dermatitis.
    BMS-981164
  • HY-148695B
    ADR58 sodium
    Inhibitor
    ADR58 sodium is a highly potent and selective human oncostatin M (OSM) antagonist, which can prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. ADR58 sodium can be used in the research of rheumatoid arthritis related diseases.
    ADR58 sodium
  • HY-P991284
    QX-005N
    Inhibitor
    QX 005N is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. QX 005N can be used in research related to asthma.
    QX-005N
  • HY-N3421
    Koaburaside
    Inhibitor
    Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC50 of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase.
    Koaburaside
  • HY-144373
    IL-17 modulator 6
    Modulator
    IL-17 modulator 6 (compound 61) is a potent Interleukin 17 (IL-17) modulator (pIC50=9.1). IL-17 modulator 6 has the ability to inhibit IL-17 and can be used for the research of inflammatory and autoimmune diseases.
    IL-17 modulator 6
  • HY-171837A
    t9,t11,c15-CLNA
    Inhibitor
    t9,t11,c15-CLNA is a conjugated linolenic acid (CLNA) isomer produced by Lactobacillus plantarum ZS2058. t9,t11,c15-CLNA has the main activities of anti-inflammatory, antioxidant and improving intestinal barrier function. The regulatory mechanism of t9,t11,c15-CLNA includes upregulation of tight junction proteins, inhibition of pro-inflammatory cytokines (such as TNF-α, IL-6) and activation of antioxidant enzymes (such as SOD, CAT). t9,t11,c15-CLNA can be used in the study of inflammatory bowel diseases (such as colitis).
    t9,t11,c15-CLNA
  • HY-P991150
    Ompekimig
    Inhibitor
    Ompekimig is a humanized immunoglobulin monoclonal antibody targeting human interleukin 4 (IL-4) and interleukin 13 (IL-13). Ompekimig is promising for research of immune-mediated inflammatory diseases, such as asthma and atopic dermatitis.
    Ompekimig
  • HY-115910
    Y13g
    Inhibitor
    Y13g is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g reverses the STZ (HY-13753)-induced memory deficit, and shows histopathology similarly as in normal animals.
    Y13g
  • HY-172111
    EGFR-IN-144
    Inhibitor
    EGFR-IN-144 (Compound 4B) exhibits inhibitory activities against EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). EGFR-IN-144 exhibits cytotoxicity in multiple cancer cell with GI50 of nanomolare levels. EGFR-IN-144 downregulates the expressions of mTOR, TNF-α, and IL-6, arrests the cell cycle at G1/S phase, and induces apoptosis.
    EGFR-IN-144
  • HY-P991438
    XmAb-662
    Inhibitor
    XmAb-662 is a fusion protein targeting IL-12. XmAb-662 can be used in solid tumours research.
    XmAb-662
  • HY-RS06713
    IL1A Human Pre-designed siRNA Set A
    Inhibitor

    IL1A Human Pre-designed siRNA Set A contains three designed siRNAs for IL1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IL1A Human Pre-designed siRNA Set A
    IL1A Human Pre-designed siRNA Set A
  • HY-P991218
    Anti-IL11 Antibody (X203)
    Inhibitor
    Anti-IL11 Antibody (X203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-IL11 Antibody (X203)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity

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